Supplement Recommendations for MCAS & Histamine Intolerance

Explore our selection of supplements specifically recommended for managing MCAS & Histamine Intolerance. We understand the importance of finding the right products to support your health needs.

🧬 Supplement Recommendations for MCAS & Histamine Intolerance

Why Supplements Matter

If you’re living with Mast Cell Activation Syndrome or Histamine Intolerance, you know how sensitive your body can be to even the smallest triggers. Targeted supplements can support your immune system, stabilize mast cells, and improve your ability to break down histamine—helping you feel more in control.

We’ve curated a list of the most effective, well-tolerated supplements based on the latest research and patient experiences.

🌿 Top Supplement Categories

1. Mast Cell Stabilizers

These help calm down overactive mast cells that cause inflammation and allergic-type reactions.

  • Quercetin – A natural flavonoid that stabilizes mast cells and reduces histamine release.

  • Luteolin – Works similarly to quercetin but may be better tolerated by some.

  • Perilla Extract – Anti-inflammatory and helps reduce allergic responses.

2. Histamine-Degrading Support

Supports your body’s ability to break down histamine effectively.

  • DAO (Diamine Oxidase) Enzyme – Helps break down histamine from food; best taken before meals.

  • Vitamin B6 – A cofactor for DAO production.

  • Copper – Supports DAO enzyme function (low-dose, only if needed).

3. Nutritional Deficiencies Common in MCAS

Many with MCAS are deficient in key nutrients that affect immune and histamine balance.

  • Magnesium Glycinate or Threonate – Calming, anti-inflammatory, and gentle on the stomach.

  • Vitamin C (Buffered) – Natural antihistamine and immune support.

  • Zinc – Important for immune regulation and mast cell stability.

  • Omega-3 Fatty Acids (DHA/EPA) – Anti-inflammatory support.

4. Gut Health Support

An unhealthy gut can worsen histamine sensitivity.

  • Probiotics (Low Histamine Strains) – Like Lactobacillus rhamnosus GG or Bifidobacterium infantis.

  • Glutamine Powder – Supports gut lining repair.

  • Aloe Vera Extract – Soothes inflammation and supports healing.

⚠️ Important Note

Everyone with MCAS and histamine intolerance is different. Start low and slow with any new supplement. Always consult with a healthcare provider who understands your condition before starting a new supplement regimen.